Manchester United defender Lisandro Martinez is expected to be out for two to three months with a foot injury.
The 25-year-old Argentina international missed the end of last season after fracturing a metatarsal in April.
He returned to action at the start of this season but United say he will be sidelined again because of “an aggravation” to the injury.
The club said Martinez “experienced the setback in our Premier League game against Arsenal earlier this month”.